Using antibodies to bind to extracellular tau species, preventing them from being taken up by healthy neighboring neurons.
Small Phase I studies have shown ASOs are safe and can reduce aggregated tau. Current Challenges and Clinical Status antitauon
In the context of neurodegenerative research, "antitauons" refer to or therapeutic agents designed to neutralize tauons —the prion-like, pathological forms of the tau protein that spread from neuron to neuron. Overview of Tauons and Antitauons Using antibodies to bind to extracellular tau species,
Using antisense oligonucleotides (ASOs) or "intrabodies" to reduce tau levels within the cell. antitauon