Disorder - Depressive

Diagnosis typically requires a persistently low mood or decreased pleasure in most activities for at least two weeks.

: Significant changes in appetite or weight, sleep disturbances (insomnia or hypersomnia), and psychomotor agitation or retardation. depressive disorder

Because MDD is multifactorial, no single mechanism explains every case. Leading scientific hypotheses include: Major Depressive Disorder - StatPearls - NCBI Bookshelf Diagnosis typically requires a persistently low mood or