: Flag variants that bind too strongly in low-calcium environments (often linked to bone issues).
Because PLS3 mutations can cause different diseases depending on how they affect calcium response, this feature could simulate how a specific variant behaves under varying calcium levels: PLS3.7z
: Automatically differentiate between loss in spongy (trabecular) bone versus the hard outer (cortical) layer, as PLS3 variants typically affect trabecular bone more severely. : Flag variants that bind too strongly in
If you are developing a tool or database for this data, here are several features based on its scientific properties: 1. Dynamic Calcium-Sensitivity Modeling PLS3.7z
A specialized module to predict the skeletal "fragility score" based on the mutation type found in the archive: