When things go wrong, TG2 shifts roles. In the extracellular space, it binds to integrins and acts as a co-receptor, facilitating cell adhesion and migration.
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Inside the cell, TG2 contributes to survival pathways. However, its dysregulation is linked to celiac disease, fibrosis, and tumor progression, making it a critical player in disease research. When things go wrong
TG2 acts as a "molecular glue," crosslinking extracellular collagen and fibronectin to help stabilize tissue structure, making it vital for wound healing. TG2 contributes to survival pathways. However