Transferase

Transferases are found throughout the cell, with high concentrations in the cytosol, mitochondria, and Golgi bodies. Molecule of the Month: Glutathione Transferases - PDB-101

Transferases are officially classified under the Enzyme Commission (EC) system as . They follow a general reaction formula:

), critical for DNA methylation and gene expression regulation. transferase

: Transfer acyl groups, vital for fatty acid metabolism and the synthesis of structured lipids. Biological Roles

: Transfer phosphate groups (typically from ATP) to substrates, a process essential for cell signaling and metabolic regulation. Aminotransferases (EC 2.6) : Transfer amino groups ( −NH2negative cap N cap H sub 2 Transferases are found throughout the cell, with high

: Transfer sugar moieties to form glycosidic bonds, which are essential for synthesizing blood group antigens and modifying drug stability.

) between an amino acid and a keto acid, playing a key role in amino acid metabolism. : Transfer methyl groups ( −CH3negative cap C cap H sub 3 : Transfer acyl groups, vital for fatty acid

A transferase is an enzyme that catalyzes the transfer of a specific functional group (such as a methyl or phosphate group) from a donor molecule to an acceptor molecule. These enzymes are vital for metabolic pathways, including the synthesis and degradation of carbohydrates, proteins, lipids, and nucleic acids. Core Mechanism and Classification